尿管完全閉塞の尿生成機序におよぼす影響について

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A study was made of the effect of total ureteral occlusion on renal function in 27 mongrel dogs weighing 5-12.5 kg (Fig. 1). Total unilateral ureteral occlusion was performed in 23 dogs, and the intrapelvic pressure was measured. Intravenous infusion of normal saline with 1.6-9.0 ml/h/kg body weight caused the intra pelvic pressure to rise and reach a constant level in 61.3±12.0 (S.D.) minutes. The intrapelvic pressure at this stage was 61.8±14.7 (S.D.) mmHg (Fig. 2). At the time when the elevated intrapelvic pressure became mostly stable, the glomerular filtration and tubular PAH secretion were investigated. At the stage when the elevated intrapelvic pressure became mostly stable, 18 dogs were injected intravenously with 150 mg of Inulin per kg of body weight and 4 mg of PAH per kg of body weight, and sacrificed 1 hour later. Inulin and PAH were demonstrated in the pelvic urine on the occluded side of all the 18 dogs. The Inulin and PAH amounts found in the pelvic urine on the occluded side were 29.3±14.0 (S.D.)% and 35.5±16.3 (S.D.)% of the counterparts in the contralateral normal kidney (Table 1 and 2). The bilateral renal blood flows were simultaneously measured in 11 dogs. The renal blood flow on the occluded side increased as the intrapelvic pressure rose after occlusion of the ureter (Fig. 3). The renal blood How increased by 22.5% on the average over the control flow 30 minutes after occlusion of the ureter, and by 34.6% on the average at the stage when the elevated intrapelvic pressure became stable.
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尿管完全閉塞の尿生成機序におよぼす影響について

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