腎結石発生機転に関する電子顕微鏡的研究 : 特に近位尿細管の管腔内所見について

概要

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We performed electron microscopic studies on the mechanism of renal stone formation, using dd strain male mice which were given Vitamin D_2. The results obtained were as follows. 1. Koch's colloidal microbodies (about 300 to 500mμ in diameter) which showed circular structure were observed in the proximal tubular lumen. It was found that these microbodies passed through the brush border in between the microvilli and were transported into the tubular epithelium. These microbodies increased in size and number and revealed concentric circle structure which contained layered membranes and the lumen was filled with these microbodies. In the microbilli of brush border were observed disorder and destruction. 2. Electron dense tubular invaginations were seen and lysosomes which showed electron dense and myelinic structure were increased in number. Mitochondrial matrix revealed clear alteration, swelling and disappearance of the cristae.
社団法人日本泌尿器科学会の論文
1975-08-20