実験的腎動脈狭窄腎における組織学的研究 : 旁糸球体装置を中心として

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1) A histologic study of the kidney, espedally the juxtaglomerular apparatus (J.G.A.), was made in 47 rabbits with unilateral stenosis of the renal artery and in 13 control rabbits. Relationship between the degree of constriction and the time relation of histologic changes was investigated. 2) Hypertension was produced in 64% of moderately, 38% of lightly, and 24% of highly constricted groups. Namely moderate constriction produced hypertension on the highest percentage. 3) The injury of tissues increased in proportion to the degree of constriction. It first manifested itself in renal tubules and then glomeruli and interstitial tissues. Changes in the vascular system appeared later. No significant relationship was observed between the development of hypertension and the histologic changes except J.G.A. 4) J.G.A. itself suffered injury by high constriction and lost its function. 5) It was observed how J.G.A. respond following the constriction and concluded that J.G.A. respond in a manner expected of a secretory gland. In addition it was made clear that J.G.I. is able to be applied after one week. 6) The author devised an index of juxtaglomerular apparatus (I.J.G.A.) in order to evaluate hypertrophy and hyperplasia of J.G. cells and demonstrated its usefulness.
社団法人日本泌尿器科学会の論文