化学療法剤の前立腺組織ならびに精液内移行に関する研究 : 第2報 Erythromycin, Aminobenylpenicillin-Methylchlorophenylisoxazolylpenicillin および Sulfamethoxazole-Trimethoprimについて

概要

論文の詳細を見る
The levels of EM and ABPC-MCIPC in the prostatic tissue and the prostatic fluid of the dog were determined. l . EM : The maximum concentration in the prostatic tissue after single oral dose of EM 50 mg/kg was 2.20 μg/g and prostatic tissue/serum ratio was I .49. The maximllm level of EM in the prostatic fluid was 8.95 μg/ml and prostatic fluid/serum ratio was 4.40. 2. ABPC-MCIPC : The concentrations in the prostatic tissue and the prostatic fluid after single oral dose of ABPC 25 mg/kg and MCIPC 25 mg/kg was scarcely detectable. The concentrations of SMX-TMP in the seminal plasma of normal adult and in the adenoma tissue of patients with prostatic hyperplasia were determined. 1 . SMX : The maximum concentration of SMX in the prostatic tissue after single oral dose of SMX 800 mg and TMP 160 mg was 20.6 μg/g and prostatic, tissue/serufh ratio was 0.366. The maiimum level in the seminal plasma was 6.5 μg/ml and semen/serum ratio was 0.151. 2. TMP: The maximum concentration of TMP in the prostatic tissue was 6.89 μg/g and prostatic tissue/serum ratio was 3.82. The maximum level of TMP in seminal plasma was 5.75 μg/ml and semen/serum ratio was 2.90.
社団法人日本泌尿器科学会の論文