腎結核と自律神經機能 : 第4報人の結核腎組織ホモジネート健常家兎皮下連續注射並にB.C.G.感作家兎腎實質内人型結核菌接種の血清Ca及K量に及ぼす影響

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The purpose of this study is to observe the influence of various tuberculpus materials on serum calcium and potassium. Materials used in this study were homogenate of normal human kidney, that of tuberculous human kidney and ,emulsion of caseous substance in tuberculous kidney. Supernatant fluid of each material was subcutaneously injected into normal rabbits for 20 days every other day. Other group of rabbits, previously sensitized with BCG, was injected with tubercle bacilli into the left renal parenchyma after ascertaining the positive Romer's reaction. Serum calcium and potassium were determined in every grou.p. The results were as follows; 1) In the group treated with normal kidney homogenate, neither the increase nor the decrease of Ca, K and K:Ca ratio was beyond the normal limits. 2) In the group treated with tuberculous kidney homogenate, remarkable decrease in Ca and temporal increase in K as well as in K:Ca ratio were observed. 3) In the group treated with tuberculous kidney homogenate, from which protein had previously been removed by heating at 1000C for 2 hours, a ternporal decrease in Ca and a temporal increase in K as well as in K:Ca ratio were observed. These changes were. however, Iower that in the group treated with unheated homogenate. 4) Specific precipitin was proved in serum of rabbits treated with tuberculous kidney homogenate. However, the heated homogenate did not show such an antigenicity. 5) In the group treated with tuberculous kidney homogenate, considerable decrease in Ca and increase in K and K:Ca ratio were brought about by an intravenous injection of a small amount of the same homogenate. On the other hand, considerable increase in Ca and decrease in K and K:Ca ratio were brought about by an intravenous injection of a small amount of heated homogenate in the majority of rabbits which had been sensitized with the same antigen. 6) In the group treated with caseous substance, decrease in Ca, increase in K and temporal increase of K:Ca ratio were observed. 7) In the group injected with tubercl'e bacilli in renal parenchma after a BCG sensitization, serum Ca increased considerably 20 days after the injectio.n of tubercle bacilli. There-after, however, serum Ca was apt to decrease gfadually. The serum K and K:Ca ratio in this group increased immediately after the injection either of BCG or tubercle bacilli. They decreased, however, 20 days after the injection in case of tubercle bacilli. They increased again thereafter. In case of BCG injection, a high level of K and K:Ca ratio was maintained without any temporal decrease.
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腎結核と自律神經機能 : 第4報人の結核腎組織ホモジネート健常家兎皮下連續注射並にB.C.G.感作家兎腎實質内人型結核菌接種の血清Ca及K量に及ぼす影響

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腎結核と自律神經機能 : 第4報 人の結核腎組織ホモジネート健常家兎皮下連續注射並にB.C.G.感作家兎腎實質内人型結核菌接種の血清Ca及K量に及ぼす影響

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腎結核と自律神經機能 : 第4報人の結核腎組織ホモジネート健常家兎皮下連續注射並にB.C.G.感作家兎腎實質内人型結核菌接種の血清Ca及K量に及ぼす影響