尿路***の正常および腫瘍組織における ABH 同種抗原の検討 : 特に前立腺と膀胱について

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The study was done with the use of specific red cell adherence test (SRCA), a modification of Coombs' mixed cell agglutination test, to examine the presence or abscence of ABH isoantigens in normal urogenital tissues, as well as their change in the evolution of carcinoma in those tissues. 1) The ABH isoantigens were strongly present in the glomerulus and the collecting duct of the kidney, the transitional epithelium of the pelvis, ureter, bladder, and urethra, and weakly in the seminal vesicle and epididymitis, but are absent in the tubulus in the kidney. 2) The ABH isoantigens are present in 22 of 30 cases of benign prostatic hyperplasia, but only in 2 of 23 cases of prostatic cancer. 3) In the bladder, the ABH isoantigens are present in 11 of 16 cases of normal epithelium, 2 of 2 cases of the Brunn's nest, 0 of 1 cases of ca. in situ, 16 of 48 cases of low grade tumor, and O of 11 cases of high grade tumor. This study confirmed the previous findings in other organs; the loss of tissue ABH isoantigens corresponds with the degree of anaplasia. 4) Positive ABH isoantigens in the low grade papillary transitional carcinoma of the bladder seemed to correlate well with low incidence of tumor recurrence as 3 of 12 cases with positive ABH isoantigens showed recurrence for at least 3 years, while 17 of 23 cases without ABH isoantigens did so. The 2 cases, in whom the cancer became eventually invasive and caused cancer death, did not show ABH isoantigens even in their original low grade tumor. SRCA is an immunohistological method that is expected to improve the diagnosis, therapy and survival in the low grade bladder cancer.
社団法人日本泌尿器科学会の論文
1979-12-20

尿路***の正常および腫瘍組織における ABH 同種抗原の検討 : 特に前立腺と膀胱について

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