ラットを用いた実験的神経因性膀胱における膀胱壁内自律神経について

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The autonomic innervation was investigated morphologically in the wall of the normal and experimentally induced neurogenic bladders of male rats. Observations were made of the adrenergic fibers by fruorescent histochemical technique and of the acetylcholinesterase-positive fibers by enzymatic histochemical technique. The results obtained were as follows. 1) Adrenergic fibers terminated, after the arrival at the bladder neck with the inferior branch of the vesical artery, in large numbers in the muscle of the bladder neck but not in that of the body of the bladder. 2) It seemed to be sure that adrenergic fibers in the muscle of the bladder neck changed their neurons in the pelvic ganglia, according to the studies after severance of the hypogastric nerve, ligation of the inferior branch of the vesical artery, proximal ligation of the vesical artery and destruction of the pelvic ganglia. 3) A small number of grouped acetylcholinesterase-positive and negative cells were observed outside the bladder wall near the vesicoureteral junction but not within the bladder wall. 4) There were a greater number of acetylcholinesterase-positive fibers in the logitudinal muscles than in the circular muscles in both the neck and the body of the bladder. 5) Bilateral severance of the pelvic splanchnic nerve was followed by disapperance of acetylcholinesterase-positive fibers in some bundles of muscle but not in other bundles, the findings which suggests the presence of 2 types of fibers: fibers involved in direct innervation from the micturition center in the sacral part of the spinal cord and those with alternating neurons. 6) The pelvic splanchnic nerve appeared to innervate the urinary bladder bilaterally based on the studies after unilateral and bilateral severance of the pelvic splanchnic nerve.
社団法人日本泌尿器科学会の論文
1979-12-20

ラットを用いた実験的神経因性膀胱における膀胱壁内自律神経について

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