腎結核に於ける化学療法打切り時期の判定法に関する研究 : 特に尿異染反応定量法について

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For the recent period of 5 years and 10 months 131 cases of renal tuberculosis have been observed and treated. In principle, the concomitant use of SM, PAS and INAH was made in all cases, and nephrectomy was performed in 54 cases. On the one hand, the effects of treatment were followed in cases of renal tuberculosis by means of the quantitative method of metachromatic reactions (MR) in the urine. Chemotherapy was stopped when MR continued to be negative for more than 6 months. Results: 1) MR in the group receiving the operation with the combined use of chemotherapy turned negative earlier than in the group receiving chemotherapy alone. 2) Among the chemically-treated group, the negativity of MR was not attained in cases of tuberculosis of both kidneys, in cases of tuberculosis of the remaining kidney, and in cases with tuberculous complications of organs other than the urinary tract. 3) At the point of continuous negativity of MR, the urines were all negative for bacillus tuber culosis. proteins and leucocytes, while the blood sedimentation rate was normal, and improvements of renal functions and pyelographs were noticed. 4) The quantitative MR correlates well with the active pathological changes in the tuberculous lesions of the kidney and hence the metachromatic reactions are deemed to be of high value as an index to the determination of the point of chemotherapy stoppage.
社団法人日本泌尿器科学会の論文