酸化セルローズを用いた腎癌の動脈塞栓術

概要

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Transcatheter arterial embolization of renal cell carcinoma was performed by infecting a mixture of oxidized cellulose and contrast medium in 1O cases. Water-soluble contrast medium was added to minced oxidized cellulose and stirred well until white viscous suspension was obtained. The suspension containing oxidized cellulose was injected gradually into the renal artery under careful fluoroscopic control. No untoward effect except fever and pain in the renal region was noted. After an initial rise of serum glutamic oxalacetic transaminase, glutamic pyruvic transaminase, lactic dehydrogenase, alkaline phosphatase and creatine phosphokinase, they returned to their normal levels within 2 to 4 weeks after embolization. Transient rises of plasma renin activity and blood pressure was observed. Ease of surgery was noted when radical nephrectomy was performed within a short interval after embolization. However, no reduction of tumor metastasis took place after embolization. Blastogenesis examined by concanavalin A and phytohemagglutinin revealed a lowered immune response in patients with renal cell carcinoma which persisted after embo1ization. The immune response was stimulated after radical nephrectomy. Oxidized cellulose is a safe and suitable embolizing agent for a short term embolization of renal cell carcinoma.
社団法人日本泌尿器科学会の論文