膀胱腫瘍に対する抗腫瘍剤マイトマイシン C および放射性同位元素^<32>Pの膀胱内注入療法 : (II) M.M.C の膀胱内注入に関する基礎的研究 (膀胱組織内濃度)

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II. Concentrations in the Vesical Tissues. 1. In sexually mature rabbits and in adult dogs with artificial submucosal vesiculations in the bladder, the concentration of MMC in the mucosa and submucosa containing vesicles following intracavitary instillation at high concentrations was found to practically parallel degree of the submucosal vesiculation in both species of animals. Specimens with high degree of vesiculation showed a tissue level of MMC of as high as 45.4 mcg/gm in rabbits and of 2.2 to 2.8 mcg/gm in adult dogs, whereas with specimens with virtually complete subsidence in vesicle formation, the concentration was a slow as 1.48 mcg/gm in rabbits and 0.08 to 0.11 mcg/gm in adult dogs respectively. It follows from these findngs that high tissue concentrations of MMC are usually achieved in affected are as wherever inflammation and edematization are present with in the bladder. 2. There was no evidence of close relations of the intramuscular concentration of MMC to the degree of submucosal vesiculation, however. Intramuscular level of the compound following intracavitary administration ranged in rabbits from 0.59 to 0.62 mcg/mg and in dogs from trace to 0.26 mcg/gm, which are obviously by far higher than after intravenous injection.
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