膀胱腫瘍に対する抗腫瘍剤マイトマイシン C および放射性同位元素 ^<32>P の膀胱内注入療法 : (I) マイトマイシンおよび ^<32>P の膀胱内注入に関する基礎的研究 (血中濃度)

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Intracavitary radiation and chemotherapy with cytotoxic agents are usually indicated for tumors of the bladder with, reportedly, some success in attaining complete disappearance, or contraction of the tumor and prevention of neoplastic regeneration. However, laboratory studies published concerning these techniques of therapy as yet are few. The present investigation was under taken to determine blood and vesical tissue levels of the antitumorgenic agent mitomycin C (referred hereinafter to as MMC) and of radioisotope ^<32>P following intravesical instillation as well as to follow histological changes of the bladder and tumor. A clinical study was also performed in a series of 25 patients to determine whether the intracavitary treatment might be beneficial in ameliorating the grade and stage of the vesical tumor.
社団法人日本泌尿器科学会の論文