尿路結石症における尿中hydroxyprolineの研究

概要

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The values of urinary free and total hydroxyproline (HOP) were measured by the method of Prockop and Udenfriend in 10 patients without any active disease that could be considered to affect the collagen metabolism as well as in 56 patients with urolithiasis. The results were as follows : A significantly high excretion of urinary HOP was observed in 8 patients with urolithiasis and 6 of them were suspected of primary hyperparathyroidism by other biochemical examinations. Moreover, of 48 patients with urolithiasis showing the normal value of urinary HOP, 5 were suspected of primary hyperparathyroidism by other examinations. The urinary excretion of free HOP was 3 to 4% of the total HOP in most patients, but the patients, who had been confined to bed, showed an increase of free HOP. Nine patients without urolithiasis and 55 patients with urolithiasis were subjected to the calcium infusion test, which was described by Howard et al. While no alteration of free HOP could be observed in either group, the total HOP showed a noticeable decrease on the day of infusion, but on the day after infusion, both groups showed a significant increase in total HOP; but the urolithiasis group still remained below the original level. Farthermore, when parathyroid extract was administrated to 2 non-urolithic patients and 2 patients with urolithiasis, no influence upon the total HOP was observed.
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