前立腺と肝障害に関する研究 : 特に前立腺発癌実験を中心として

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In order to clarify the physiological relationship between the prostate and liver, an animal experiment was conducted: prostatic tumors were induced with 20-methylcholanthrene and hepatic injuries with carbon tetrachloride. Histological studies of the prostate of autopsied patients with cirrhosis orcancer of the liver were also under taken. In the animal experiment, histological changes in the prostate and incidence of prostatic tumor in rats with hepatic injury were investigated. In the first group, 0.1 ml of Tween-80, containing 3 per cent 20methylcholanthrene, was injected into an anterior lobe of the prostate. In the second group, 0.1ml of olive oil, containing the same volume of purified carbon tetrachloride, per 100g of body weight, was subcutaneously injected into the back twice a week. In the third group, the 20-methylcholanthrene solution (M.C.T.) was injected in the same way as mentioned above, following which this group was divided into 4 subgroups. These subgroups then received a subdermal injection of the carbon tetrachloride solution (C.T.C.) 1,2 (early administration), 3 and 4 months (late administration) later, respectively. All the rats died within 200 days after the injection of M.C.T. The prostate was removed and fixed and sections were studied microscopically. The results obtained were as follows:
社団法人日本泌尿器科学会の論文