ヒト尿性カリクレインの研究

概要

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On the purpose to investigate the physiological role of kallikrein in the human kidney, its activity in human urine (Human urinary kalikrein; H.U.K.) was determined by TAME (p-toluene sulfonyl-l-Arginine methyl ester) assay described by Moriya. The values obtained with this method well correlated to those obtained as kinin releasing activity where released kinins were assayed by observing the contraction of isolated guinea pig ileum. To obtain normal range, 6 healthy males and females were examined. The results were as follows: male, average 63 E.U. per day (ranged 0-126); female, avrerage 39 E.U. per day (ranged 0-68). H.U.K. activity in patients with primary aldosteronism showed significant high values. In patients with Cushing's syndrome, renal lesions and others were within normal range. H.U.K. in primary aldosteronism decreased after extirpation of the adrenal adenoma. H.U.K. activities in 7 cases of renal homotransplantation were determined serially. Soon after the transplantation, most cases of them showed extremely low levels but in some cases showed relatively high levels.
社団法人日本泌尿器科学会の論文