実験的阻血腎の血流再開後における微細構造の変化 : 特に腎尿細管細胞についての研究

概要

論文の詳細を見る
A model of ischemic kidney was produced in rats by temporary occlusion of the renal pedicle. Occlusion was maintained for 30, 60 and 90 minutes. Then, ultrastructural changes of the renal tubules during developmental sequence following subsequent reflow of blood to the kidney were studied by electron microscopy. Blood reflow was permitted for 30, 60 or 120 minutes or 24, 48 or 72 hours or 7 days.The main changes were as follows : 1) Brush border was fragmented and absent from the apical membrane. Considerable amounts of brush border debris could be seen in membrane bound vacuoles within the cells. 2) Early changes of mitochondria were marked swellings. Then, mitochondria showed tem-porarily normal structure, and became pyknotic. 3) Myeline-like structures were seen in apical and basal region of the cell in the early stage. 4) Extracellular compartments were extended especially by a 90 minutes occlusion. These changes may be related to necrosis of the cell. But, we still think that they show an abnormal metabolic system of the organelle in the cell and that they are related to the renal function.
社団法人日本泌尿器科学会の論文