ラジオアイソトープを用いた膀胱容量測定法予報

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If continuous recording of the intravesical volume from outside of the body using a simple apparatus becomes possible, it will surely be helpful in the physiological and pathophysiological study of the urinary bladder. Principle and method. A certain amount (30 μ Curie) of isotope (^<131>I-hippuran) was put into the bladder and suprapubic radioactivity during the process of bladder expansion was continuously recorded with a special collimeter (2 cm in diameter) and correlated with the intravesical volume. a) Study with ballon. After 30 μ Curie of the isotope was instilled into the balloon, water was poured in steps. Tip of collimeter was fixed at the height of 5 cm from the center of the empty balloon. Recorded radioactivity decreased stepweise and it was well correlated with the instilled water volume. b) Study with dog's bladder. Isotopic solution was instilled into the dog's empty bladder and the lower abdominal midline radio-activity was recorded at the point of O, 5, 10 and 15 cm cephalad to the pubic symphysis, at the skin surface. The radioactivity was heighest at I O cm cephalad to the symphysis in middle sized dogs, and at 5 cm in small dogs. Next, the collimeter was placed at the point of the heighest radioactivity and recording was made during the stepwise retrograde instillation of water into the bladder. The result was the same as in the case of balloons, showing a stepseise decrease of radioactivity in accordance with increasing water volume. c) Study in clinical cases. At first 30 μ Curie of ^<181>I-hippuran was instilled into the empty bladder of a male adult and radio-activity at the skin level of the low abdominal midline was recorded during retrograde water instillation. This was repeated by shifting the collimeter on the skin. The curve shows the mount-shaped pattern, and its peak point was dependent upon the distance of collimater from the pubic symphysis. The water volume at the peak of tie curve in this case was respectively 10 cc, 50 cc, 250 cc and 400 cc when the distance frorrL the symphysis was 0 cm, 2 cm, 4 cm ahd 6 cm. The peak was higher when the recording place is nearer to the pubic symphysis. Therafter we recorded the radioactivity in the following rnanner : At first 20 ml of isotope solution was instilled into the empty bladder and the point of maximum count was found out in the midline. (Usually, it was at the upper edge of the pubic symphysis, but in some cases 1 or 2 cm cephalad to it.). The collimeter was fixed at this point and then radioactivity was recorded during the stepwise dilution of radioisotope.
社団法人日本泌尿器科学会の論文
1974-12-20

ラジオアイソトープを用いた膀胱容量測定法予報

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