蓚酸塩結石発生過程に関する走査型電子顕微鏡学的研究

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When Diet 13 B, containing oxalic acid in a ratio of 2%, was orally administered to dd-strain male mice for 50 days, progress of oxalate stone development in the kidneys of these mice was traced by means of scanning electron microscope. The following results were obtained. 1. In the lumen of the proximal tubules, not only deposit of non-crystalline and irregular structures mainly composed of degenerated epithelial cells but granular or globular structures of various sizes could be recognized. Some pictures indicated that a portion of these structures was being taken into the tissue through the spaces between the microvilli of the brush border. In those pictures, the brush border was generally disarranged and partially destructed or fallen. In addition, the cytoplasm of these tubular epithelial cells became thinner and flat, and it was characterized by vesicles, increased vacuoles, distinct nucleus and evident mitochondria. At this experimental stage, deposit of irregular octahedral crystals was already found out on the luminal surface of the proximal tubules. The pictures to suggest the developmental process from non-crystalline structure to crystalline one with various sizes proved that crystal deposition resulted in fall of the brush border, destruction of epithelial cell structure, and cellular flattening. 2. The experimental results observed in the thinner portion of Henle's loop could be summarized as follows; non-crystalline multiform structural material of which central portion had already crystallized first appeared, and its central crystallized portion then cumulatively grew up in a fashion of lamellae or wavelets, some of the crystals being columnar, needle-like or polygonal plates. On the free surface of the epithelial cells, there were of course microvilli and single cilium. The nuclei of these cells became flat. In the cytoplasmic matrix, vacuoles were evidently observed.
社団法人日本泌尿器科学会の論文
1976-10-20

蓚酸塩結石発生過程に関する走査型電子顕微鏡学的研究

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