射精の研究 : 第8報射精と脳内モノアミン

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The effects of psychotropic drugs both on ejaculation, which was induced by manual stimulation of the penis in dogs, and on the brain contents of catecholamines (CA) and serotonin (5HT) in dogs and rats were investigated. The results obtained are as follows: I) Effects on ejaculation in dogs. 1) Although erection was maintained after administration of 0.063mg/Kg of reserpine i.p., ejaculation was almost suppressed by the drug. When 50mg/Kg of L-dopa was administered i.p., ejaculation was recovered to the extent before the administration of reserpine. As the doses of reserpine increased to 0.125 and 0.5mg/Kg, the rate of dogs which maintained erection decreased, and ejaculation was suppressed completely. Administration of L-dopa, 50mg/Kg, i.p., also recovered ejaculation in these dogs. 2) After administration of tetrabenzaine, 100mg/Kg, i.p., erection was maintained in all dogs, but ejaculation was suppressed. Administration of L-dopa, 50mg/Kg i.p. recovered ejaculation. 3) When 50 and 25mg/Kg of L-5-hydroxytryptophan (L-5HTP) administered i.p. to 4 dogs, erection was suppressed in 3 of 4 dogs examined, and ejaculation was suppressed in all dogs. Administration of 12.5mg of 5-HTP suppressed ejaculation, although erection was maintained. 4) Administration of p-chlorophenylalanine (pCPA), 100mg/Kg once a day for 3 days did not change ejaculation. When L-5HTP 12.5mg/Kg i.p. was administered to the dogs, ejaculation was suppressed, although erection was maintained. 5) When haloperidol, 3-4mg/Kg, was administered i.v., erection was maintained but ejaculation was suppressed. In dogs, to which 5mg/Kg of haloperidol was administered, both erection and ejaculation were suppressed.
社団法人日本泌尿器科学会の論文

射精の研究 : 第8報射精と脳内モノアミン

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射精の研究 : 第8報 射精と脳内モノアミン

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射精の研究 : 第8報射精と脳内モノアミン