膀胱発癌に対するtryptophan代謝産物の役割に関する研究 : 第II編 FANFT(初発因子), l-tryptophan(促進因子)によるマウス膀胱発癌実験

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In order to investigate the role of l-tryptophan's promoting factor on tumorgenesis in the urinary bladder, the following experiment was contemplated. Sixty D-D strain female mice of 7-week-old were fed 0.1% FANFT added CE-2 diet for 4-week duration. Thereafter, these mice were divided into two groups each comprising thirty mice 0.2% l-tryptophan added CE-2 diet for one group (group-1) and CE-2 diet for another (group-2) were fed for those mice in respective groups for another 56 weeks. Results: 1) There were two cases of bladder tumor among the group-1 mice. 2) Both labeling index and hyperplastic index were statistically significant (t=2.78, p<0.05) in group-1 mice when compared with group-2. From these results L-tryptophan's promoting factor on tumorgenesis in the urinary bladder seemed to be undeniable.
社団法人日本泌尿器科学会の論文