化学療法剤の前立腺組織ならびに精液内移行に関する研究 : 第1報 Cephalexin, DoxycyclineおよびSulfamethoxazole-Trimethoprimについて

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Prostatic tissue and seminal plasma levels of chemotherapeutics (CEX, DOTC and SMX-TMP) were determined in humans and in dogs. 1. CEX: Prostatic tissue/serum ratios in dogs were 23-53% (mean 34.6%) and that in humans were 10-65% (mean 43.7%). Prostatic fluid/serum ratios in dogs were 1.3-5.1% (mean 3.1%) and Seminal plasma/serum ratios in humans were 0.5-2.4% (mean 1.7%). 2. DOTC: Prostatic tissue/serum ratios in dogs were 21-80% (mean 43.9%) and that in humans were 25-300% (mean 97.7%). Prostatic fluid/serum ratios in dogs were 16-47% (mean 26.8%) and Seminal plasma/serum ratios in humans were 23-44% (mean 35.1%). 3. SMX-TMP (only in dogs) SMX: Prostatic tissue/serum ratios were 45-48% (mean 46.4%) and Prostatic fluid/serum ratios were 12.7-28.9% (mean 18.4%). TMP: Prostatic tissue/serum ratios were 2.6-8.0 fold (mean 4.5 fold) and Prostatic fluid/serum ratios were 7.5-27 fold (mean 13 fold).
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