家兎下顎骨の欠損腔に対する多孔質ヒドロキシアパタイト顆粒の応用に関する実験的研究

概要

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The recent development of biomaterials, especially of ceramics including hydroxyapatite has been remarkable. The present study was performed in oder to investigate histopathologically the healing process of the bone defects to porous hydroxyapatite granules (P-HAP granules) which was implanted into artificially created bone defects in domestic rabbits. The results were as follows : 1. At one week after implantation in bone defects, P-HAP granules could be observed in the granulation tissues composed of fibroblasts and collagen fibers. There was slight inflammatory cell infiltration. 2. At two weeks after implantation, P-HAP granules could be observed in the fibrous connective tissues. The formation of osteoblastic cells was seen around them. 3. After four weeks, P-HAP granules were encapsulated by new bone tissue and were directly connected with new bone tissue. Neither foregin body reactionnor inflammation cells infiltration was observed. 4. After six weeks, P-HAP granules were embedded in the new bone. Bone repairs were almost completed incontrol. The formation of new bone was rather expedited as compared with control. 5. Considering above results, it was suggested that P-HAP granules were non-inflammatory and non-stimulative. Further they had good tissue tolerance and osteogenic activity. In these investigations, P-HAP granules are considered to be useful as bone graft material for oral surgery.
九州歯科学会の論文
1994-06-25