ラット各組織における樹状細胞とマクロファージの分布

概要

論文の詳細を見る
Distributions of dendritic cells and macrophages were examined by frozen sections of submandibular lymph nodes, spleen and ear of rats, using specific monoclonal antibodies : KO 3, direct for dendrintic cells ; ED 1, direct for macrophages ; OX-3, direct for Ia antigen. The results were as follows : 1. KO 3 reacted with veiled cells in the subcapsular sinus and interdigitating cells in the paracortex of lymph nodes, and Langerhans cells in the epidermis of ear. These facts support the hypothesis that these dendritic cells are the same cell lineage. 2. KO 3-positive cells in these tissues also reacted with OX-3 (expressing Ia antigen). This indicates that the dendritic cells are antigen-presenting cells. 3. In lymph nodes, interdigitating cells are KO 3-immunopositive, but not in spleen. This result suggests that interdigitating cells in spleen differ from the cells in lymph nodes. 4. The distribution of dendritic cells appearently differed from that of OX-3-positive cells (macrophages) in these tissues. This result suggests that among antigen-presenting cells, dendritic cells differ from macrophages in the role and the field where they play their role. Thus monoclonal antibody KO 3 reacted with part of local dendritic cells, as Langerhans cells in epidermis and veiled cells and interdigitating cells in lymph nodes. This KO 3 is a useful device for the research in oral immunology.
九州歯科学会の論文
1991-08-25