鼓索神経切断後のラット顎下腺の変化に関する実験的研究
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概要
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Using rats experimentally subjected to tympanichordal preganglion-parasympathectomy, the author recently examined histopathological changes in submandibular gland and obtained the following results : 1. As early as three days after the neurectomy, atrophy and degeneration of gland cells at a marginal portion of the submandibular gland and vascular dilatation and congestion and fibrous connective tissue hyperplasia in interstitial connective tissue were noted. These changes progressed with the lapse of time. 2. Twenty-one days thereafter, remarkable atrophy and degeneration of gland cells and dilatation and deformation of the excretory duct with disappearance of intraluminal saliva-like substance were noted all over the submandibular gland. High hyperplasia of fibrous connective tissue and infiltration of inflammatory cell were noted in interstitial connective tissue. 3. Twenty-eight days thereafter, morphological recovery of atrophied gland cells at the hilus portion was noted, and fifty-five days thereafter, substantial recovery of these cells and lobular structure of decreased, fibrous connective tissue hyperplasia were noted all over the submandibular gland. Ninety days thereafter, findings similar to those of the control group were generally presented. 4. These atrophic and degenerative changes in the submandibular gland tended to originate in its marginal portion and to extend and progress to its hilus portion, and these regenerative changes tended to extend and progress from its hilus portion to its marginal portion with the lapse of time. 5. Throughout the experimental period, plexus and ganglia in the connective tissue of the hilus portion did not disappear after the neurectomy. The above results revealed temporary morphological atrophy and degeneration of the submandibular gland following tympanichordal preganglion-parasympathectomy and its subsequent regeneration with the lapse of time.
- 九州歯科学会の論文
- 1989-06-25
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