口腔領域における扁平上皮癌患者の Carcinoembryonic Antigen (CEA) に関する臨床的研究

スポンサーリンク

概要

• 論文の詳細を見る

• The tumor markers are divided roughly into tumor-specific substances and tumor associated substances. Since no materials biosynthesized specifically by tumor cells have yet been discovered, tumor-associated substances have been applied widely and clinically as tumor markers for determination of clinical diagnosis and effect of treatment and monitoring progress and prognosis. Carcinoembryonic antigen (CEA), among various tumor markers, has been known to appear with high positive rates not only in patients with gastrointestinal cancer but also in those with malignant tumor in another organ. Clinical utility of this fact has been attracting attention. Sixty-five patients with squamous cell carcinoma in the oral cavity were therefore examined for serum CEA level and localization of tissue CEA (indirect peroxidase-antiperoxidase method) and clinical evaluation was made. The results were as follows : 1. The average serum CEA of 65 patients with oral cancer (squamous cell carcinoma) was 3.06±3.89 ng/ml and the positive rate was 38.5% (25/65 cases). In contrast, the average for control patients with benign oral disease was 1.60±0.51 ng/ml and the positive rate was 5.8% (3/52 cases). Statistical significance difference was found. 2. With progress of clinical stage, namely, as the tumor grew and the lesion developed, serum CEA level gradually increased its average and positive rate. Also, in comparison with primary cancer, advanced cancer showed higher values in many cases. 3. The posotive rate of tissue CEA was 59.5% (25/42 cases) on the whole. With the progress of clinical stage of oral cancer, the positive rate tended to increase gradually. 4. The average serum CEA of the cases of cancerous tissue CEA-positive was 4.44±1.82 ng/ml. That of cancerous tissue CEA-negative was 1.90±0.56 ng/ml and statistical significance was found between the two (p<0.01). In the cancerous tissue CEA-positive, there were many cases of serum CEA-positive. In the tissue CEA-negative cases, many tended to be serum CEA-negative. 5. By prognosis, the average of serum CEA level and positive rate for good prognosis cases were 2.21±0.49 ng/ml and 18.4% (7/38 cases), respectively. For poor prognosis cases, they were 4.09±2.71ng/ml and 59.3% (16/27 cases), and statistical significance difference was found (p<0.01). 6. As to change in serum CEA level before and after treatment, serum CEA level tended to decrease and become negative after treatment for the cases of good prognosis. For the cases of poor prognosis, serum CEA level was unchanged or increased in many and tended to become negative. With imminent death especially, serum CEA level was markedly high. 7. On the basis of the foregoing findings, serum CEA level well reflects the extent of the tumor and severity of conditions. Serum CEA level is though to be a useful indicator for estimating progress, effect of treatment, and prognosis. Its clinical untility is considerable.

• 九州歯科学会の論文
• 1988-10-25

著者

• 山野 貴教

  九州歯科大学口腔外科学第2講座

• 山野 貴教

  九州歯科大学

関連論文

• 特発性血小板減少性紫斑病の 1 例
• 32. 上顎嚢胞性疾患の病理組織学的検索(第 32 回九州歯科学会総会報告)
• 50. 嚢胞性疾患の X 線所見と手術所見の対比について(第 30 回九州歯科学会総会ならびに学術講演会)
• 33. 鶏胚骨の培養に関する研究 : 第 3 報唾液腺ホルモンの影響について : 中, 高濃度群(第 29 回九州歯科学会総会ならびに学術講演会)
• 58. 孵化鶏卵の大腿骨に及ぼす唾液腺ホルモンの影響について(第 4 報)(第 29 回九州歯科学会総会ならびに学術講演会)
• 口腔領域における扁平上皮癌患者の Carcinoembryonic Antigen (CEA) に関する臨床的研究 : 主論文の要旨
• 口腔領域における扁平上皮癌患者の Carcinoembryonic Antigen (CEA) に関する臨床的研究
• in vivo level(Nude mouse)における各種制癌剤の効果判定に関する実験的研究-1-Nude mouseに対する各種悪性腫瘍移植実験に関する成績
• 口腔領域における悪性腫瘍患者のCEAについての検討
• Lymphoepithelial cyst of the ventral surface of the tongue - Report of a case.:Report of a case
• 口腔領域悪性腫瘍患者における腫瘍マーカーについての検討

もっと見る 閉じる

スポンサーリンク