PCB 投与によるラットエブネル腺の微細構造的変化

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概要

• 論文の詳細を見る

• Ultrastructural changes of the von Ebner's gland of the rat were examined by transmission electron microscopy with use of 0.1% polychlorinated biphenyls diet (PCB group) and vitamin-A-deficient diet (V.A def. group). Weaning male rats aged 3 weeks, weighing 38-45g, were used in this study. The results obtained are as follows : 1. Pair-fed controls increased their body weight during the experimental period. Growth rates of the two experimental groups were markedly decreased as compared with their controls. The animals fed PCB began to show depilation, diarrhea and eye mucus. 2. Vitamin A content in serum of the rats fed on 0.1% PCB diet decreased to onethird of that of controls, suggesting that PCB causes reduction of vitamin A in serum. 3. The secretory granules of the acinar cells of the rats fed on 0.1% PCB diet were stained less by toluidin blue than those of the rats given control diet. 4. Electron microscopically, the nuclei of the acinar cells showed irregular outlines and pyknosis after 0.1% PCB diet feeding. Rough endoplasmic reticulum cisternae were remarkably enlarged. Golgi apparatus was atrophied and it produced myelin figures. Some mitochondria contained myelin figures and irregularly arranged cristae. Large vacuoles and autophagic vacuoles were increased in number. Lumen and intercellular canaliculus were expanded. Myelin figures and/or membraniform substances appeared in the lumen. 5. Structural changes of the acinar cells induced by vitamin A deficiency were the same as those induced by PCB except for myelin figures in mitochondria. Namely, the nuclei of the acinal cells showed pyknosis. Cisternae of the rough endoplasmic reticulum were strongly enlarged and contained less electron-dense amorphous substances. Autophagic vacuoles contained scroll-like lamellae and lipid droplets. Large vacuoles contained myelin figures and amorphous substances. The secretory granules fused with each other. These fused granules appeared less dense than the nonfused granules. Acinal lumen and intercellular canaliculus distended and they contained membraniform substances. 6. The granules of the duct cells treated with PCB were fewer than controls. Many dense granules were observed in the apical portion of the vitamin-A-deficient epithelia and the apical surfaces of the cells showed apocrine processes.

• 1988-04-25

著者

• 下田 妙子

  九州歯科大学口腔解剖学第2講座

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