ラット歯髄内 LPS 接種後の破骨細胞および骨髄細胞の変動
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概要
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Lipopolysaccharide (LPS) in dental plaque is thought to be an inducer of the periodontal disease accompanied with the resorption of the alveolar bone. LPS was applied into the root pulp of rats to clarify the effect of LPS on the number of bone cells. The rats were sacrificed on appropriate days after the application. Medullary cells and osteoclasts were disaggregated from the alveolar bone of the applied side and from that of the opposite side. The number of the cells was counted. Tooth and periodontal tissues were also examined pathologically. The results were as follows. 1. In the applied side, the number of the medullary cells decreased rapidly after 3 to 5 weeks, and then recovered nearly to the level of the control. In the opposite side, the number decreased and recovered earlier than that in the applied side. 2. The number of osteoclasts changed with a similar profile in both sides of the alveolar bone. The number greatly decreased after 3 weeks, and increased after 4 weeks. After 5 weeks in the applied side, the number was twofold higher than that of the control. In the opposite side, the number was at the similar level of the control. 3. In the pathological findings, cell infiltration was recognized weekly at the root pulp after one week and it increased gradually. The degenerated layer formed after 2 weeks and reached the apical crest after 4 weeks. A focus was formed around the apical crest after 4 weeks. 4. In pathological findings, resorption was recognized at the apical crest after 3 weeks, and the crest became smooth. Resorption was seen at the alveolar bone neighbouring the apical crest. The area of resorption at the alveolar bone widened and resorption lacunae were often seen on the bone surface. 5. In pathological findings, medullary cells disappeared in part of the medullary cavity after 4 weeks. Most medullary cells disappeared after 5 weeks. The net number of osteoclasts decreased first and then increased after LPS-application. It seemed that bone resorption was accompanied with the increase in the number of osteoclasts. Medullary cells were highly sensitive to LPS and decreased in number by this application.
- 九州歯科学会の論文
- 1988-02-25
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関連論文
- ラット歯髄内 LPS 接種後の破骨細胞および骨髄細胞の変動 : 主論文の要旨
- ラット歯髄内 LPS 接種後の破骨細胞および骨髄細胞の変動
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