家兎の顎下腺における VX2 癌の増殖に関する実験的研究

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Oral cancer has been known to invade the surrounding soft tissue and jaw bones in its early stage. In the oral cavity particular, the mode of its invasion and growth is varied and not uniform, because of the anatomical complexity in structure. It is therefore necessary to have sufficient knowledge of its mode of proliferation in order to achieve desirable treatment results. The author therefore transplanted VX2 carcinoma in the submandibular glands of normal domestic rabbits and made a histopathological investigation of its proliferation behavior and the accompanying changes in the submandibular glands. The results were as follows : 1. VX2 carcinoma transplanted in the submandibular glands of domestic rabbits proliferated and enlarged with time and invaded along the intralobular and interlobular connective tissues into the glandular tissue. Furthermore, the invasion gradually degenerated and destroyed the acinous cells of the terminal portion. The tumor cells proliferated while invading in cord-like manner. The tumor cells enveloped and destroyed the striated and interlobular ducts and showed findings of changes leading to cytolysis and necrosis. Meanwhile, as the VX2 carcinoma tissue invaded and proliferated tumor cells showing morphological regressive changes were observed in the striated and interlobular ducts or in the venous system. 2. With invasion by and proliferation of VX2 carcinoma tissue, round cells, consisting mainly of lymphocytes, invaded and appeared to surround the tumor tissue in the glandular tissue. In the acinous cells of the terminal portion in particular, extensive regressive changes were observed. Such regressive changes increased in extent and degree with time. However, changes of such degrees were not observed in the striated and interlobular epithelial cells of the ducts. 3. With the invasion by and proliferation of VX2 carcinoma tissue, regressive changes occurred in the submandibular gland. As a result, PAS positive substance decreased in the acinous cells of the terminal portion. The invasion and proliferation not only induced regressive changes in the salivary gland tissue morphologically but also affected synthesis of the secretory substance and excretion functionally. 4. In the present experiment, proliferation of VX2 carcinoma was observed in the submandibular glands of domestic rabbits. The present experiment is considered to be useful as a model of experimental salivary gland cancer along with other oral cancer models reported to date.
九州歯科学会の論文
1984-04-25

家兎の顎下腺における VX2 癌の増殖に関する実験的研究

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