制癌剤の骨創治癒におよぼす影響に関する実験的研究
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Chemotherapy for oral cancer is an important treatment method following surgery and radiotherapy. A speedy healing of wounds morphologically and functionally in the postoperative period is particularly desirable. On the other hand, an extended administration of anticancer agents is necessary for prevention of local recurrence and metastasis. In view of these, a histopathological investigation was conducted on the effect of Bleomycin and Mitomycin C on healing process of the bone defects experimentally made in the mandibular bones of domestic rabbits. For contrast, Prednisolon was selected. Each agent was administered by group in high-dose and in low-dose. The results were as follows : A. In the group treated with Bleomycin in high-dose (3.0mg/kg/day), a closer relationship to an increase in the amount of dosage and the number of administration was found in : retardation of appearance and proliferation of fibroblasts ; retardation of formation, proliferation, and maturity of granulation tissues ; and retardation of maturity of the newly formed bone trabeculae. However, no significant decrease in the degree of formation of the newly formed bone trabeculae was found in comparison with the Control group. Similar findings in a less degree were also found the group treated in low-dose (1.5mg/kg/day). B. In both groups treated with Mitomycin C in high-dose (0.5mg/kg/day) or in low-dose (0.25mg/kg/day), a closer relationship to an increase in the amount of dosage and the number of administration was found in : retardation of appearance and proliferation of fibroblasts ; retardation of formation, proliferation, and maturity of granulation tissues ; and a decrease in the degree of formation and retardation of maturity of the newly formed bone trabeculae. In the 20-times administered cases, in particular, transudation of erythrocytes through the blood vessels was found in places in the bone defect. In the group treated in low-dose (0.25mg/kg/day), no significant difference was found in comparison with the Control group, although a slight delay in healing was observed. C. In both groups treated with Prednisolon in high-dose (5.0mg/kg/day) or in lowdose (2.5mg/kg/day), a closer relationship to an increase in the amount of dosage and the number of administration was found in : retardation of appearance and proliferation of fibroblasts ; retardation of formation, proliferation, and maturity of granulation tissues ; and a decrease in the degree of formation and retardation of maturity of the newly formed bone trabeculae. These findings were more evident in the group treated in high-dose than in the group treated in low-dose. D. All of Bleomycin, Mitomycin C, and Prednisolon showed a retarding effect. The degree of delay in healing was in the descending order of Prednisolon, Mitomycin C, and Bleomycin. No peculiar histopathological changes were found in any agents or in any experimental group during the present experiment.
- 九州歯科学会の論文
- 1980-03-25
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