顎関節疾患の病態形成における細胞と細胞外マトリックスについての研究

概要

論文の詳細を見る
Recently, many lines of evidence indicated that variable degrees of inflammation exist in temporomandibular disorders (TMD). Synovial fluid (SF) analysis of the temporomandibular joint (TMJ) has revealed that a variety of inflammatory mediators and components of the matrices of the articular cartilage are detectable in the TMJ. We performed SF analysis for the inflammatory cytokines and nitric oxide (NO) in the SF of the TMJ. It is demonstrated that cytokines such as interleukin 1 (IL-1) are frequently detectable in the SF from patients with TMD, not from the asymptomatic controls. Nitric oxide was also detectable mainly from the patients. Furthermore, inducible nitric oxide synthase (iNOS) was expressed in the synovium of the patients with TMD. Hyaluronic acid (HA), a high-molecular-weight polysaccharide, plays a major role in joint lubrication. We demonstrated that the molecular weight of HA in SF from patients with TMD, not from healthy volunteers, is decreased. These data suggested that IL-1 and NO seem to be related to the pathophysiology of the certain types of the TMD. These data also suggested that mechanical stress caused by overloading results in the generation of free radicals such as NO. These radicals may cause degradation of hyaluronic acid, which in turn impairs the joint lubrication and function in patients with TMD.
九州歯科学会の論文
2003-08-25