心筋切片の呼吸に關する研究(第3報) : 強心配糖體の影響

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概要

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• The influence of cardiac glycosides-stroph-anthin, digitoxin, digoxin and digicorin-upon respiration of rat heart muscle slices was studied using the manometric (Warburg) technique described in Part I of this article.Results were as follows.1) Oxygen consumption in 0,01 M glucose medium and 100 per cent O_2 was increased by 10^<-5>-10^<-6> M strophanthin and digoxin, but decreased contrarily by 10^<-5>-10^<-7> M digitoxin and 10^<-4>-10^<-6> M digicorin. (Table 3. Fig 3)2) Similarly, oxygen consumption in 0,01 M lactate medium was increased by strophanthin and decreased by digitoxin. (Table 4 (1) A (2) A Fig 4 A)3) In 0,01 M pyruvate medium, oxygen consumption remained unchanged, though slices were exposed to strophanthin or digitoxin. Table 4 (1) B. (2) B Fig 4 B)4) When gas was air, oxygen consumption of slices in 0,01 M glucose medium was decreased by both sitrophanthin and digitoxin. These findings were against to some other's reports that in hypoxemia cardiac glycosides accelerate the permeability of O_2. (Table 5. Fig 5)5) Analyzing the above mentioned data, the mechanism of the action of cardiac glycosides was discussed. It is interesting to see that cardiac glycosides have no uniform effect as far as cardiac muscle slices respiration is concerned, depending upon its kind. Different kinds of cardiac glycosides in same medium showed different effect on O_2 consumption of cardiac muscle slices. Same kinds of cardiac glycosides in different medium showed different effect on it.The above two facts hardly explain to author true picture of the action of cardiac glycosides. Experiments using heart muscle slices are usually more useful than experiments in vivo, analyzing biochemical changes. But slices don't perform any mechanical work of heart, moreover it is not in the same condition as cardiac insufficiency, in which cardiac glycosides are most effective. Therefore, the author feels that the data obtained from heart muscle slice experiments hardly explain the principle of cardiac glycosides action.

• 社団法人日本循環器学会の論文
• 1955-11-20

著者

• 宮原 光夫

  札幌醫大・内科

• 宮原 光夫

  東京大學醫學部内科學第一講座

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• 心筋切片の呼吸に關する研究(第4報) : ビタカンファー・アドレナリン及びアセチルヒョリンの影響
• 心筋切片の呼吸に關する研究(第3報) : 強心配糖體の影響
• 心筋切片の呼吸に關する研究(第2報) : 乳酸菌及び焦性葡萄酸を基質とする呼吸
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