心筋切片の呼吸に關する研究(第4報) : ビタカンファー・アドレナリン及びアセチルヒョリンの影響

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Author observed the influence of vitacampher, adrenalin and acetylcholine on respiration of rat's heart muscle slices, using the same method described in Part III of this article. As substrate 0.01 M glucose and as gas pure oxygen was used.Results were as follows.1) Vitacampher depressed respiration markedly. It was more marked when vitacampher-concentration was higher. (Table I, Fig. 1)2) Adrenalin depressed respiration contrary to the experiment in vivo reported by many workers. This was more marked when adrenalin-concentration was higher, just as in vitacampher experiment.(Table II, Fig 2)3) Acetylcholine had reverse action on respiration, namely accelerated respiration. Then this too, was contrary to the experiment in vivo. But in higher concentration of acetylcholine it was depressive. (Table III, Eig. 2) 4) It was found that cardiac glycosides about which action was described in another report No. 3,vitacampher, adren alin and acetylcoline, all showed similar depressive action in their higher concentration.
社団法人日本循環器学会の論文
1955-12-20