Contribution of Bystander Effects in Radiation Induced Genotoxicity

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概要

• 論文の詳細を見る

• The controversial use of a linear, no threshold extrapolation model for low dose risk assessment is based on the accepted dogma that the deleterious effects of ionizing radiation such as mutagenesis and carcinogenesis are attributable mainly to direct damage to DNA. However, this extropolation was challenged by the recent reports on the bystander phenomenon. The bystander effect contributes to this debate by implying that the biological effects of low doses, where not all cells are traversed by a charged particle, are amplified by the transfer of factors to un-irradiated neighbors. This interested phenomenon implies that a linear extrapolation of risks from high to low doses may underestimate rather than over estimate low dose risks. Together with some radiation-induced phenomena such as adaptive response and genomic instability, the radiobiological response at low doses is likely to be a complex interplay among many factors.

• 長崎大学の論文

著者

• SUZUKI Masao

  International Space Radiation Laboratory, National Institute of Radiological Sciences

• Hongning Zhou

  Center For Radiological Research College Of Physicians And Surgeons Columbia University Medical Cent

• Zhou Hongning

  Center For Radiological Research Columbia University

• Suzuki Masao

  International Space Radiation Laboratory National Institute Of Radiological Science

関連論文

• Mutation Induction in Cultured Human Cells after Low-dose and Low-dose-rate γ-ray Irradiation : Detection by LOH Analysis
• Qualitative and quantitative difference in mutation induction between carbon- and neon-ion beams in normal human cells
• Mitochondrial Function Modulates Cytoplasmic Irradiation Induced Bystander Effect
• Consequences of Cytoplasmic Irradiation : Studies from Microbeam
• Effects of Irradiated Medium on Chromatid Aberrations in Mammalian Cells Using Double Mylar Dishes
• 127 Effects of Irradiated Medium on Chromatid Aberrations in Mammalian Cells(Effects of space radiation, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
• Induction of a Bystander Chromosomal Damage of He-ion microbeams in Mammalian Cells
• Bystander chromosomal alterations induced in mammalian cells using a charged particle microbeam.
• LET and Ion-species Dependence for Mutation Induction and Mutation Spectrum on hprt Locus in Normal Human Fibroblasts
• LET and Ion-species Dependence for Cell Killing and Mutation Induction in Normal Human Fibroblasts
• Radiation Biology, Theoretical strategy:How to make treatment planning for heavy ion-beam therapy ?
• Apoptotic Sensitivity of Cultured Mouse Brain Cells to Low Dose Rate Irradiation of Heavy Particles
• Contribution of Bystander Effects in Radiation Induced Genotoxicity
• Heavy Charged Particles Produce a Bystander Effect via Cell-Cell Junctions

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