馬杉腎炎に及ぼす下垂體, 副腎皮質ホルモンの影響

概要

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With pituitary-adrenocortical hormon (DOCA, Cortisone and ACTH) administed to rabbits with Masugi-nephritis, a study was made of the influence of these hormones on the appearance of nephritis from the view points of variation of blood pressure, albuminuria, a decrease of the complement and the variation of serum protein accompanied by a histological survey.(1) When DOCA was given, variation of blood pressure, the appearance of albuminuria and a decrease of the complement were found at the earlier stage than a control case.It was also considered that the appearance of nephritis and severity of the disease were accelerated, on the basis of serum protein and from a histological view point.(2) In case of Cortisone and ACTH, as to variation of blood presure, the apperance of albuminuria and a decrease of the complement, changes were not so remarkable as in a control case. In that respect Cortisone and ACTH did not seem to check the appearance of nephritis.Although it was interesting that some qualitative variation had developed in Masugi-nephritis, pathological changes in the glomerulus had been mitigated especially following the administration of Cortisone. Still, a nephrotic pattern was indicated in serum protein of each case as mentioned above.
社団法人日本循環器学会の論文
1957-10-20