酵母ペルオキシソームの機能と発達の分子生理学的研究とその展開

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概要

• 論文の詳細を見る

• Peroxisomes (microbodies), one of the subcellular organelles, have been shown to have indispensable functions in the metabolism of n-alkanes, fatty acids, methanol, and several nitrogen-containing compounds in eukaryotic microorganisms after we described the appearance of large numbers of the organelles in an n-alkane-assimilating yeast, Candida tropicalis. It has been suggested that peroxisomes proliferate by division from already existing peroxisomes and their characteristic proteins, which are encoded by nuclear genes, have been shown to be specifically localized after synthesis outside peroxisomes. These physiological phenomena can be controlled simply by changing the carbon and/or nitrogen source for growth, making microorganisms an excellent target to investigate the biogenesis of peroxisomes in eukaryotic cells. Development of peroxisome is accompanied by the increases in the cellular levels of the peroxisomal enzymes more or less. This monograph deals with the functions of peroxisomes in alkane metabolism by yeasts, together with discussion about the mechanisms of their development and degradation as well as the properties and application of peroxisomal enzymes. More fundamental understanding of the mechanism of peroxisomal biogenesis than that reviewed in this monograph may lead to the application of these systems to various fields. Analysis of such interesting phenomena using microorganisms will contribute to an understanding of the functional compartmentation of various components into subcellular organelles in eukaryotic cells.

• 公益社団法人日本生物工学会の論文
• 1994-07-25

著者

• 植田 充美

  京都大学工学部合成・生物化学教室

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