メチルオレンジを滴定液とした二相イオン対滴定のよる錠剤, 散剤及び注射液中のマレイン酸クロルフェニラミンの定量

概要

論文の詳細を見る
Chlorpheniramine maleate (CPM) in tablet (CPM-T), powder (CPM-P) and injection (CPM-I) forms according to The Japanese Pharmacopoeia Thirteenth Edition (JP-XIII) was determined by the two-phase photometric ion-pair titration (TPPIT) method using Methyl Orange (MO) as the titrant. Ten ml of a buffer solution (pH 5) and 40 ml of dichloromethane (DCM) were added to a sample containing about 0.5 mg CPM and titrate in a 1×10^<-3> M MO standard solution ; the solution was then stirred for 2 minutes. After the solution was separated into layers, the absorbance of the DCM layer was measured at 425 nm. By repeating this operation, a titration curve was prepared and the titration end point was obtained. The amount of CPM was calculated, and compared with that determined by the JP-XIII method. No significant difference was found in the accuracy between the two methods. Therefore, the TPPIT method is a useful method for the determination of CPM.
社団法人日本分析化学会の論文
1997-02-05