Eremothecium ashbyiiの深部培養によるビタミンB_2の工業生産 : (IV)滅菌条件, 消泡剤および汚染防止剤のB_2生産に対する影響

概要

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Several fundamental experiments were made in order to prevent bacterial contamination. The results obtained are as follows : 1) Conditions for sterilizing some kinds of media in several vessels were confirmed. In the experiment using a medium containing cane molasses and fish meals, no change of riboflavin production occured on sterilizing at 121℃, 1/2 or 1 hour, but riboflavin production was decreased to 73 and 65% in case of 3 and 5 hours sterilization. 2) Test of 6 kinds of antifoam agents showed that a small amount of them did not exert inhibitive effect on riboflavin production. 3) Culture of Eremothecium ashbyii was contaminated when incubated in a medium containing 3% of glucose, 3% of fish meal and 4-10mg% of 2-(5 nitro)-furfuralsemi-carbazone after heating at 100℃ for 1 hour.
日本ビタミン学会の論文