血中ビタミンB_1,とくにその血漿, 血球内分布に関する臨床的研究 : (II)ビタミンB_1剤負荷時の血中ビタミンB_1量とその血漿・血球内分布
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The author determined the content of thiamine in whole blood and its distribution in plasma and blood cells when administering thiamine hydrochloride, thiamine propyldisulfide and cocarboxylase, and obtained the following results : After administering the above thiamine preparations, the thiamine increases in plasma as a free form, and then shifts to blood cells after being phosphorylated in body. When administering the above preparations for a long time, the esterified thiamine is saturated first in blood cells (25 μg/dl in blood cells, while 10 μg/dl in whole blood), and then the total thiamine becomes saturated in whole blood. The free thiamine, however, hardly increases in blood cells. Based on the above findings, the author states that the determination of the esterified thiamine in blood cells is more adequate than that in whole blood as a criterion of the thiamine deficiency.
- 日本ビタミン学会の論文
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