血中ビタミンB_1,とくにその血漿, 血球内分布に関する臨床的研究 : (I)諸種疾患時の血中ビタミンB_1量とその血漿, 血球内分布

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Thiamine level in blood, especially its distribution in plasma and blood cells, was determined in various diseases. The total thiamine level in the blood of 20 healthy subjects averaged 8.2±0.4 μg/dl, and no significant difference was found between male and female. Free thiamine was 0.9±0.3 μg/dl in average and found only in plasma, while a majority of esterified thiamine averaged 7.3±0.4 μg/dl, and existed in blood cells. The thiamine level in whole blood was lower in various diseases than that of healthy subjects. Especially in beriberi, hepatocholecystocholedochopathy with jaundice, pyloric prolapse and antrospasm, or neuromyopathic diseases, the content of esterified thiamine in blood cells was less than 4.0-4.5 μg/dl, and the concentration was lower than 10 μg/dl. Based on the above findings, the author concluded that it was very important to determine not only the thiamine in whole blood, but also the esterified thiamine in blood cells in order to diagnose the deficiency of thiamine.
日本ビタミン学会の論文