抗生物質のビタミンA代謝に及ぼす影響 : (III)ペニシリン投与がシロネズミ肝, 小腸, 血清中ビタミンA量に及ぼす影響ならびにビタミンA負荷試験

概要

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The effect of penicillin on the vitamin A contents of liver, small intestine and blood serum in rats was studied. Penicillin was added to the diet at the rate of 20000 units per kg of body weight, and after one, two, three and four week feeding vitamin A level was determined. The vitamin A content of liver was gradually increased two times after four weeks feeding, whereas that of blood serum was decreased slightly two and three weeks feeding, but in four weeks it was restored to normal level, and vitamin A level in small intestine showed insignificant changes, as compared with control groups. The vitamin A content of liver, small intestine and blood serum was determined one, three, six and twenty four hours after an intravenous injection of 1 mg per kg of body weight of vitamin A to the rats reared on penicillin-containing diet. The result showed that the vitamin A content of liver reached the maximum after three hours and the liver storage of vitamin A was accelerated by feeding on penicillin containing diet.
日本ビタミン学会の論文
1959-00-00