投生物質投与時のビタミンB_1代謝に関する組織化学的研究 : (I)オーレオマイシン大量投与シロネズミの臓器組織のビタミンB_1分布

概要

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Changes of distribution of thiamine in various organs of rat were investigated histochemically, when 200 mg per kg per day of Aureomycin was orally administered for 3 days to 4 weeks. A marked change was recognized in the liver, for example, in the case of 3 days administration, thiamine decreased remarkably followed by a pathological transformation. When 500 μg of thiamine was given after the Aureomycin administration, the thiamine contents increased in all organs, but the increase in the liver was small. These results indicate that the decrease of thiamine in the organs was not due to the inhibition of bacterial thiamine synthesis in the intestine, bu to the disturbance of thiamine phosphorylation.
日本ビタミン学会の論文