抗生物質投与時の肝および脳におけるビタミンB_1代謝とα-ケトグルタル酸々化 : (IV)アクロマイシン少量投与時のビタミンB_1代謝とα-ケトグルタル酸々化

概要

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Thiamine content and α-ketoglutarate oxidizing activity in liver of rats, orally administered with 20mg/kg/day of Achromycin increased in parallel temporarily at the beginning, decreased during the second and the third weeks, and again increased in the fourth week. No change in the ratio of free to esterified thiamine was noticed. By addition of cocarboxylase to liver homogenate, with lowered α-ketoglutarate oxidizing activity, the activity was regained but not to a sufficient degree. In the control rats, the α-ketoglutarate oxidizing activity of liver or brain homogenate showed a slight increase by the addition of Achromycin.
日本ビタミン学会の論文