抗生物質投与時の肝および脳におけるビタミンB_1代謝とα-ケトグルタル酸々化 : (III)アクロマイシン大量投与時のビタミンB_1代謝とα-ケトグルタル酸々化

概要

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When 20mg/kg/day of Achromycin was given to young rats the growth was promoted, while it was checked when 200mg/kg/day was administered. The effects were, however, slighter than those by Aureomycin. No significant relation was noticed between the growth promotion and the nitrogen contents of liver and brain tissues. Thiamine content and α-ketoglutarate oxidizing activity in the liver of rats, administered with 200mg/kg/day of Achromycin, decreased in parallel in the second week, increased slightly in the third week and again decreased in the fourth week. In the brain they underwent no change till the sixth week. No change of the ratio of free to esterifled thiamine was observed.
日本ビタミン学会の論文