尿中ビタミンB_<12>排泄に関する実験的研究 : (II)モルモットにおける抗生物質の影響

概要

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When streptomycin (10mg) was injected every other day, urinary excretion of vitamin B_<12> for 45 to 46 hours after injection increased considerably for about two weeks, but the administration of chloramphenicol caused a prompt decrease. In the case of injection of both streptomycin (10mg) and vitamin B_<12> (1μg) every other day, the excretion of vitamin B_<12> in the 45 hours urine increased markedly on the 12th-14th day and decreased again on and after the 18th day. When streptomycin was injected intramuscularly every other day for three weeks, a marked increase of vitamin B_<12> content in liver tissue and blood was observed. The results of these experiments suggest changes in the balance of intestinal bacterial flora by the antibiotics.
日本ビタミン学会の論文
1955-00-00