尿中ビタミンB_<12>排泄に関する実験的研究 : (I)モルモットにおけるビタミンB_<12>負荷実験

概要

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When 3μg of vitamin B_<12> was injected every other day, its excretion in urine scarcely increased for the first 45 hours, but a marked increase in the 8 hours urine after injection was observed on the 13th day. It seemed that vitamin B_<12> in the body was saturated to a certain degree at the latter stage. In case of intramuscular injection of vitamin B_<12>, an increase in its excretion in urine for the 8 hours after the injection was more marked with a larger dosis (over 20μg than with a smaller dosis (under 20μg). Vitamin B_<12> content in the liver and kidneys increased markedly, by its injection in 8 hours, especially in the liver. It seemed that there was a certain limit in vitamin B_<12> content in the liver and that, when 10μg of the vitamin was administered, the liver was just saturated with the vitamin and the surplus vitamin administered was excreted in urine rapidly in free form.
日本ビタミン学会の論文
1955-00-00