抗生物質投与時のシロネズミ肝Coenzyme A代謝について : (II)クロラムフェニコールの幼若シロネズミ肝Coenzyme A代謝におよぼす影響

概要

論文の詳細を見る
In the previous paper, it was confirmed that some antibiotics, especially chloramphenicol (CP), decreased the contents of hepatic CoA and its precursors in young rats. In the present paper the effect of CP on synthesis of CoA in rat liver was studied in vivo and in vitro. 1) The simultaneous administration of CoA, pantethine or calcium pantothenate during the period of CP injection did not reveal the recovering effect on the reduced level of CoA. This decreased CoA content caused by CP returned near normal on the 3rd day after discontinuation of CP injection. 2) The activity of CoA synthesizing enzyme from phosphopantetheine in the rat liver was determined at 24 hours after 10 day's serial injection of CP 100mg/kg/day. No significant effect of CP on this enzyme was observed. However, the in vitro synthesis of CoA via this pathway using the enzyme preparation from normal rat liver was markedly inhibited by addition of CP.
日本ビタミン学会の論文
1971-09-25