抗生物質投与時のシロネズミ肝Coenzyme A代謝について : (I)数種抗生物質, 制癌剤投与時の幼若シロネズミ肝Coenzyme A量の変動

概要

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The influences of the several antibiotics injected subcutaneously and anticancer drugs administered intraperitoneally upon the hepatic pantothenic acid and CoA metabolism were investigated in young albino rats weighing 50 to 60g. 1) Followinm injection of Chloramphenicol (CP), Kanamvcin (KM) 200mm/kg daily and Penicillin G(PC-G) 100,000U/kg daily for 10 days, the hepatic content of CoA determined by Kaplan-Lipmann's method was markedly reduced, whereas it was slightly decreased by injection of Dihydrostreptomycin (DSM) and Cephalothin (CET) 20Omg/kg daily for 10 days. 2) The hepatic CoA values determined by Kaplan -Lipmann's method and Wakil's method after injection of large dosis of CP, PC -G and DSM were decreased in paralell. From these results it was presumed that these antibiotics had decreasing effect on not only hepatic CoA but also its precursors. 3) The hepatic CoA was also slightly reduced by administrations of Cyclophosphamide and Chromomycine A_3 as similar as antibiotics.
日本ビタミン学会の論文
1971-09-25