肝障害患者の尿中リポ酸排泄
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The daily urinary excretion of lipoic acid and urinary excretion after administration of lipoamide were compared, determining by microbiolgical assay between normal adults and hospitalized patients of liver diseases. The total lipoic acid contents in the urine were determined after hydrolysis by autoclaving for 1 hour with 6N HCl under nitrogen and in the presence of bovine serum albumin. The following results were obtained. No significant differences were found in the daily excretion of total lipoic acid between the normal and the patients, however the excretion of total lipoic acid in 24 hr urine after oral administration of lipoamide (30 mg) was larger on average in the normal adults (980 μg) than in the patients (698 μg). This difference was caused by the decrease (about 50% of the normal controls) of total lipoic acid in the 3 hr urine of the patients after administration.
- 日本ビタミン学会の論文
- 1969-09-25
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