Transketolaseにかんする研究 : (I)ビタミンB_1とTransketolase活性との関係

概要

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It was found that the transketolase activity of tissues of internal organs in rat with thiamine deficiency lowers and is recovered by an addition of thiamine diphosphate, in vitro (tentatively named as TDP-effect). In this case, the addition of thiamine hydrochloride to hemolysate or erythrocyte suspension is ineffective for the recovery, while various thiamine derivatives, such as thiamine propyldisulfide cause the recovery of transketolase activity. An administration of oxythiamine to rat for two weeks, causes the decrease of the enzymatic activity in all tissues, except that of brain. When 2 mg of oxythiamine was given only once to thiamine deficient rat, the TDP-effect was depressed, while the transketolase activity was not influenced. The transketolase activity and TDP-effect were tested with 63 patients suffering from various diseases. In some cases of hepatic disease and alcoholism, the hemolysate transketolase activity was recognized to decrease and TDP-effect was well correlated with thiamine deficient state.
日本ビタミン学会の論文
1967-04-25