S-Carbalkoxythiamine類にかんする研究 : (VII)O, S-Dicarbethoxythiamineの腸管吸収過程における代謝

概要

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As the oral administration of O, S-dicarbethoxythiamine (DCET) caused a remarkable increase of thiamine content in erythrocytes, which could not be attained by oral or parenteral administration of thiamine hydrochloride, it is suggested that DCET was absorbed from the intestine without being converted to thiamine in the epithelial cells and further penetrated into erythrocytes where it was metabolized to thiamine. To obtain evidence for this hypothesis, perfusion experiments in situ have been carried out. Fifty mg of DCET was administrated into a ligated sac of rabbit jejunum and portal vein blood which flowed out from the ligated part of the intestine was collected for the analysis of metabolites of DCET. About 12 % of the absorbed DCET was found in erythrocytes as thiamine and no other metabolites were demonstrated. In the plasma, on the other hand, thiamine, O-carbethoxythiamine (OCET), S-carbethoxythiamine (CET) and DCET were found in percentages of 7,11,69,13,respectively. In substitution of perfusing blood by Locke-Ringer's solution, conversion to thiamine or OCET was markedly diminished but the rate of CET formation was not affected. These results showed that DCET is mainly metabolized to CET, which still possesses a high permeability to the cells, in the intestinal absorption process.
日本ビタミン学会の論文
1966-01-25