ホモパントテン酸のパントテン酸拮抗作用について
スポンサーリンク
概要
- 論文の詳細を見る
The action of homopantothenic acid, HOCH_2C(CH_3)_2CHOHCONH(CH_2)_3COOH, a derivative of γ-aminobutyric acid, and its hydroxy-forms was examined using lactobacilli and chick. These compounds showed a pronounced competitive antagonistic action for Lactobacillus arabinosus 17-5 and Leuconostoc mesenteroides P-60. When the 50% growth inhibition of homopantothenic acid was used as the index, an inhibition ratio of 150 was obtained. In the chick given 1mg/kg a day of pantothenic acid, oral administration of more than 2g/kg of homopantothenic acid induced pantothenic acid deficiency and reduction of liver CoA. These changes could be reversed by administration of pantothenic acid. This antagonistic effct of homopantothenic acid against pantothenic acid would be attributed to an inhibitory action in the pathway of biosynthesis from pantothenic acid to CoA.
- 日本ビタミン学会の論文
- 1965-08-25
著者
関連論文
- 85.ホモパントテン酸のパントテン酸拮抗作用(II) : ヒナにたいする作用(第15回日本ビタミン学会大会研究発表要旨)
- 77.γ-アミノ酪酸の代謝について(I) : γ-アミノ酪酸の負荷実験(第12回大会研究発表要旨)
- 78.ホモパントテン酸の脳内移行およびパントテン酸との拮抗作用(第13回大会研究発表要旨)
- ホモパントテン酸のパントテン酸拮抗作用について